Genesis

The historical progress of Cialis :

• 1993: Pharmaceutical co. ICOS started its research on a compound IC351 that inhibits the PDE5 enzyme.
  
  
• 1994: Icos receives its first patent on IC351.
  
  
• 1995: First phase of clinical trials begun.
  
  
• 1997: Icos conducted the first study in patients with erectile dysfunction problem.
  
  
• 1998: Icos and Eli Lilly and Co. form a joint venture to commercialize drugs for the treatment of sexual dysfunction.
  
  
• 1999: Phase III clinical studies begin on IC351.
  
  
• 2001: New drug application is filed with the U.S. Food and Drug Administration for IC351. The company renames the drug Cialis.
  
  
• April 2002: FDA reviews drug application, saying the company must complete more clinical studies, resolve manufacturing issues and complete labeling.
  
  
• November 2002: Cialis gets European approval.
  
  
• February 2003: Marketing of Cialis begins in Europe .
  
  
• 21st November 2003: US FDA approves Cialis in United States for usage.
  
  
• December 2003: Cialis is likely to be available for sale from December.
  
  
• January 2004 : Cialis Available in USA .